Defeating melanoma broccoli help ...
One of the most dangerous human body melanoma tumors, according to various studies, has one of the highest mortality. About 75% of all cases are not amenable to treatment and end with the death of the patient. But, as reported by the journal European Journal of Medicinal Chemistry, a group of scientists managed to produce a compound that can help fight the tumor. Moreover, this compound may be obtained from the most ordinary broccoli.
It should be noted that melanoma not only has a high mortality rate, but also very quickly develops resistance to treatment received. More than 10 years ago it was discovered substances called isothiocyanates contained in broccoli and even some vegetables. They can act as prevention and treatment of cancer, but "pure" very highly toxic isothiocyanates. A team led by Dr. Arun Sharma and professor of pharmacology Shantou Amin based substance broccoli designed and synthesized a compound NISC-6 (naftalamid-izoselenotsianat). NISC-6 - is an inhibitor of an intracellular enzyme, topoisomerase reducing IIα, which contribute to the growth of melanoma.
the scientists modified the substance isolated from vegetables to reduce the toxicity level. Yielding several different connection options, each of which has been tested for toxicity and the ability to inhibit tumor growth. When exposed NISC-6 human melanoma cells are killed and tumor growth was slowed 69%.
"We created NISC-6 so that it is easily excreted from the body. This means that the toxicity of the substance in this case is much smaller than previous versions of the drug. Studies have shown that using NISC-6 manages to make a tumor to cease to be resistant to therapy, and even be a means of prevention. Thus, NISC-6 can be a very good support and therapeutic agent. "